PGS

Our Ovation Fertility team offers the latest PGS technology to patients who may benefit from genetic screening

PGS, or preimplantation genetic screening is a genetic technique that can be employed after IVF, in vitro fertilization to help determine which embryos have the normal number of chromosomes (22 pairs) and which may have an abnormal number, a condition known as aneuploidy. This helps Ovation Fertility embryologists  select the embryos which are most likely to result in a successful, healthy pregnancy.

Who benefits from PGS?

Our Ovation Fertility team may recommend PGS for women who: are at an advanced maternal age (usually age 35 or older,  have unexplained infertility, have experienced repeated implantation failure during IVF procedures, or those who have had recurrent miscarriages.

Women of advanced maternal age are at higher risk for having babies who have two of the most common conditions that result from an abnormal number of chromosomes—Down’s syndrome and Turner’s syndrome. Both of these conditions frequently cause women to spontaneously miscarry these pregnancies.

PGS is often employed by our Ovation Fertility physicians to help them evaluate embryos from women who have had recurrent miscarriages. Early pregnancy loss (during the first trimester) is usually caused by a genetic issue such as aneuploidy.

How does the PGS process work?

After the IVF process is complete, highly-trained laboratory staff gently extract (biopsy) three to five cells from the resulting embryos, on day 5, 6 or 7 after the eggs have been fertilized. Our Ovation Fertility lab professionals believe that the best method of extracting the cells is with a laser, which allows them to obtain a high-quality sample, while keeping the risk to the embryo very low.

After the biopsy, the cells are sent to one of our Ovation genetic testing laboratories for analysis.  It typically takes 7 to 10 days for the results. In the meantime, the embryos are safely in storage in the IVF laboratory, having been frozen by vitrification. The results of PGS will tell us which embryo(s) should be transferred in order to provide the highest chance for a successful pregnancy.

Research has shown that when embryos undergo PGS, there is a higher chance for pregnancy, and a lower risk of miscarriage.  PGS allows the doctors at Ovation Fertility to confidently transfer one embryo instead of more than one, essentially eliminating the risk of multiple pregnancy.

Our Ovation Fertility team is always working hard to help you build your family, and we will be happy to talk to you in detail about PGS. Contact us to learn more.

The difference between PGS and PGD

It’s easy to get confused by the terms PGS, or preimplantation genetic screening, and PGD, or preimplantation genetic diagnosis. Sometimes people think they are one and the same, but they are actually two different processes. At Ovation Fertility, our team employs PGS for certain patient populations to help identify those embryos that have an abnormal number of chromosomes. Our physicians advise patients to have PGD if they are known to either be carriers or affected by certain genetic or chromosomal disorders, such as cystic fibrosis, sickle cell anemia, muscular dystrophy, or an unbalanced translocation.

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