Research

Modified Microsecure Vitrification (MS-VTF) Procedure With DMSO-Free Solutions

Title: Modified Microsecure Vitrification (MS-VTF) Procedure With DMSO-Free Solutions

Objective: MicroSecure vitrification (µS-VTF) evolved as a non-commercial, FDA-compliant device integrating sterile flexipettes (300µmID; Cook Medical) into CBS™ embryo straws. The mean cooling rate (1391°C/min) and warming rate (6233°C/min) of this closed, aseptic VTF system were verified by Dr. Greg Fahy (Schiewe et al., 2015). In 2014, CBS removed traditional hydrophobic plugged embryo straws from the worldwide marketplace, being replaced by 0.3ml semen straws. In turn, a modification of our µS-VTF procedure (Schiewe et al., 2017) was necessary to prevent wicking of flexipette contents. The goal of this study was to clinically validate the overall performance of our µS-VTF technique for human blastocysts over a 4-year duration.

Presented at: ASRM 2019 - Philadelphia, Pennsylvania

Why This Research Helps Patients:
µS-VTF using non-DMSO, glycerol based solutions has been associated with some of the highest % healthy single term live birth rate as reported by the annual CDC/ART Surveillance survey (2014-2017). µS-VTF has continued to be safe, secure, simple and inexpensive technique.

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