Research

Clinical Benefits of Culturing Monopronucleated Zygotes Derived from Intracytoplasmic Injection Cycles

Title: Clinical Benefits of Culturing Monopronucleated Zygotes Derived from Intracytoplasmic Injection Cycles

Authors: K. Wozniak, M.C. Schiewe

Objective: To evaluate the developmental competence and aneuploidy status of blastocysts derived from monopronucleated (1PN) zygotes following intracytoplasmic injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A).

Presented: American Association of Bioanalysts (AAB)/College of Reproductive Biology (CRB) conference webinar, May 12, 2020 – Best Paper Award

Why This Research Helps Patients:
Previously, 1PN zygotes were routinely considered abnormal and were discarded. Our data confirms that 1PN zygotes can develop into euploid blastocysts. This coincides with previous work showing the potential of 1PN zygotes to develop into genetically normal blastocysts capable of producing healthy live births.

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