Independent of age, when using euploid blastocysts, we believe that SET should be adopted as the standard of care for clinics utilizing PGS. This is especially true for the first ET attempt by patients of advanced maternal age to optimize implantation rates and reduce the potential wastage of precious euploid embryos.

Based on current literature, our center implemented a 100% freeze-all strategy, with almost all cycles (87.5%) using pre-implantation genetic screening (PGS) and 80-90% of our transfers being single blastocysts. Here, we evaluate the effectiveness of a clinical strategy of routine single euploid embryo transfer (SEET) to achieve acceptable live birth rates and to try to maximize the rate of healthy singleton live births.